Have you tried Goosetown Tavern?
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One of the best open mics in Denver (Tuesdays around 9 or 10pm start). Nic Jay is a great host and the sound is always spectacular. Perfect place to meet other musicians also plugged into the scene. Decent food and rotating beer selection make it an easy place to spend a Tuesday night :)
3242 E Colfax Ave, Denver, CO 80206