I'm a huge fan of local company Tom Bihn. They make super high-quality bags and accessories that are functional and well-designed. My commuter backpack is the Synapse 19 which, despite its streamlined size, can fit 2 laptops and all my stuff due to the clever design.
They sell lots of backpacks and travel bags as well as a line of pocket-y, hook-y, and strappy accessories that allow you to customize the interior and exterior of your bag.
All their products stand up to years of hard use. Real people answer their email. And they're made right here in Seattle!